The parish of Caçarelhos, and the Village with the same name, is located in the Northern of Portugal in the interface of the Districts of Vimioso and Miranda do Douro, representing a rural community that in the field of the customs and traditions has a strong identity marked by the administrative ascendancy of Miranda to who was linked until 1853.\nThe Studies conducted by the Abade Baçal , compared with scattered trials conducted by several authors borned in the local, add little of its origin unless like the most villages in this border region of Northeast Peninsular, also Caçarelhos have been born in the castro located on the site of Castrilhouços.\nHowever dubiously, its origin dates back to the 1320 census ordered by King Dinis, although it does not mention the hardships it endured regarding the influence of the church represented for a long period at Miranda do Douro bishopric only interrupted by the domain that, before the Restoration, was, according to the author executed by the Castilians that would eventually burn and loot
In forensic analyses, sex determination is one of the crucial primary steps for human skeletal remains identification especially in missing persons and mass disasters. The present study aimed to evaluate accuracy of mandibular metric standards in estimating sexual dimorphism. A retrospective study was conducted on 92 males and 80 females of Egyptian sample. Orthopantomographs were taken for evaluating eleventh mandibular metric parameters. Four models were adopted by the stepwise discriminant analysis test to de?ne the best predictors of sex discrimination in the Egyptian population sample. All parameters were found to be significantly different between both sexes; and the most dimorphic measures were coronoid height, projective height, and mandibular canal length, followed by mandibular notch depth and condylar height. Meanwhile the least variables were gonial angle and bicodylar length. This study proves a potential sex discriminating power of mandibler indeces for personal identifications in forensic investigations.
Inflammatory bowel disease (IBD) with concomitant Primary Sclerosing Cholangitis (PSC) has recently arisen as a challenging research field. Epidemiology and characteristics of each entity separately have been investigated and our knowledge about diseases has increased. Prevalence of IBD in patients with PSC is high, estimated at more than 50%, and its distinct clinical course was proved. Based on the fact, it seems highly possible that histopathological features and genetics of IBD with concomitant PSC (IBD-PSC), vary as well. That is why, some authors propose IBD-PSC to be a distinct unit. Main goal in this field is to find out whether any genetic factors specific for IBD-PSC exist. Aim of this paper was to present review of literature on this subject and to highlight novel findings in pathogenesis of PSC associated with either Ulcerative Colitis or Crohn’s Disease.
The foundations of the angolan competitiveness, except the sectors of oil and diamonds, are the comparative advantages derived from the classical production factors: available hand labor, land and capital. In the new paradigm of regional development economy, these advantages are no longer relevant, mainly in view of the \"new\" production factor knowledge. The need to provide training courses that are more than sets of subjects (Baker & Siryk, 1989; Ferreira, 1991), and promote academic experience scenarios in which students actively participate in the construction of their training, thus stimulating self learning (eg, Fouad & Smith, 1996; Gainor & Lent, 1998; Hackett, Betz, House & Rocha-Singh, 1992; Lapan, Boggs & Morrill, 1989; Lent, Brown & Larkin, 1984, 1986; Lent, Lopez & Bieschke, 1991, 1993) are essential in this development objective. The productivity of enterprises is a complex issue, difficult to understand, where the individual must always emerge as essential in this process. Already in 1964, Blau and his Social Exchange Theory addresses the need to link processes and people, social exchanges between managers and employees maximize productivity processes in companies. Training is one of the internal processes of the hardest businesses to understand the level of organizational impact and individual (Kirkpatrick, 1979) but the level of organizational and personal development is one that translates most obvious and direct benefits to the individual through the passage of knowledge . Our work is theoretical basis the \"theories of regional imbalance\", with the most recognized representatives François Perroux (1955), Hirschman (1957 and 1958) and Kaldor (1967), the Causality Circular and Cumulative Model (Myrdal, 1957) and Model of Adjustment and Welfare under regulatory living conditions (Lent, Brown & Hackett, 2006). The common denominator of his thought was that the free play of market forces would not tend to the internal economic balance, but that the \"Back-wash effects\" (adverse effects on the periphery) more than offset the \"Spreadwash effects\" (positive effects). The differentiating factor of this work lies in the presentation of the driving force of regional development: the \"production factor\" knowledge / education and spatial differences and the under-valuation which has been subject.
objective:Impacted lower third molar is found in 90% of the general population.various degrees of post-operative complications are frequently observed in third molar extraction surgery.there fore,a surgical procedure that decreases post-operative complications should be a prior consideration for surgeons.in this study ,we compare operating time and postoperative complications between two methodsin the extraction of mandibular impacted third molars. Methods: 100patients , with an age range of 18~26, bilateral symmetrical mandible impactedthird molars on panoramic radiographs were included in thisstudy. The impactions on the left and right sideswere operated byT-shape and three sections methods,separately.Preoperative and Postoperative，medications and management were similar for two groups. The subjects were recorded operating time, root pruning situation, postoperative complications and evaluated at 24h, 48h, 120h Postoperativeoutpatient referral. Date was analyzed by t-test using SPSSl7.0 software.Results: Comparing the two techniques, we were observed a statistically significant decrease in distal parts removing time, postoperative24h facial edema and pain. While postoperative trismus and root pruning situation were no statistically significant. We also did not found any nerve lesions.Conclusion: The results of our study indicate that the surgical technique usingT-shape method likely to be a reliable method to extracthorizontal impacted third molarseasily, quickly and with less trauma to around tissue and complications.
Since this study mainly deals with which feedback students have received at the end of a learning period; if they had experienced an unfair performance assessment and how they perceive these, the focus is on the collective performance assessment, however without a closer look because it would go beyond the scope of this study. \nThe students prove the reproach of unfairness with the comparison of their achievements with that of fellow students. This study does not allow any quantitative statements about unfair performance assessments. In this study the unfair performance assessment becomes only coarsely surveyed, as perceived and narrated by the students. The estimates can be only be coarse because the consulted students are not representative of course. Nevertheless some conclusions can be drawn from the results for the future dealings with performance assessments.
This short report highlights the ability of the Strannik Virtual Scanning cognitive test to determine the pathological correlates of complex medical conditions, in particular Alzheimer’s disease.\n\nAt present there are no tests which are able to determine the complex pathological correlates of Alzheimer’s disease. The results from an SVS test may contribute to a better understanding of the condition, in particular how it can be diagnosed, and how it can be treated. This paper reports the currently available data. \n\nAn SVS test is able to qualitatively and quantitatively define from its presymptomatic origins the genetic and phenotypic components of the contributory pathologies which influence brain function - typically encephalopathy, degenerative problems in the spine and spinal ganglia e.g. arachnoiditis, ganglioradiculitis, impaired spinal circulation; which may be exascerbated by diabetes and diabetic comorbidities, in particular cardiac insufficiency; which conceivably influence insulin reactivity (and hence the biological availability of insulin to sustain brain function) and the flow of nutrients and oxygen to the brain. \n\nA number of case studies are presented and discussed which illustrate that SVS adopts a more advanced and cost-effective technique which is able to determine the onset and progression of Alzheimer’s disease than is currently available.
Electromagnetic radiation is an important factor that has a powerful influence on the organisms. Different types of radiation have different effects, while some are harmless; the ones that have high energy can determine major changes at a molecular level.\nIn order to protect themselves, many classes of algae developed different defense mechanisms, through biosynthesis of a family of compounds named mycosporine like amino acids (MAA). This MAA are capable of absorbing UV type radiation, protecting the more sensitive molecule of the cells and literature data show that these compounds have the capacity to protect human skin cells against UV rays of solar radiation.\nThe aim of this study was to determine if the MAA were able to protect mammalian cells against X-rays, an electromagnetic radiation with higher energy then UV. The radioprotection was tested using Wistar mouse fibroblast cells cultures by placing between them and the source of the radiation (between 78.37 and 173 Sv/h) an agarose gel who contains different concentrations of an alcoholic extract obtained from Ceramium genus of red algae. Viability tests and metalloproteinase profile have indicated that X-ray protection of the fibroblast culture depends on the intensity of the x-ray and the concentration of red algae extract from agarose gel.
Back ground: Total mesorectal excision (TME) is extremely important for the prevention of local recurrence of rectal cancer ,but TME is not necessarily applicable in all cases of rectal cancer: for upper rectal cancer, mesorectal excision for limited lengths of 5 cm from a tumor toward the anal side , and this method is with adequate rates of cure so we devised a new laparoscopic procedure for sufficient TSME mesorectal excision in upper rectal cancer . Operative Technique: After mobilization of the sigmoid colon we ligated the inferior mesenteric vessels, and then we dissected the mesorectum using the LigaSure™ Maryland Jaw along the layer of the planned total mesorectal excision, Then we separated the rectal wall from the mesorectum at the anal side from the tumor,then the rectum was transected using an endoscopic linear stapler, then the rectal stump was pulled immediately toward the anal side, so the mesorectum was identified clearly.Results: This technique has been successfully conducted on 50 patients with sufficient TSME easily and accurately. Conclusion: This laparoscopic technique is reliable and a feasible procedure for achieving sufficient TSME.
Introduction: Obesity has become an epidemic disease around the world and is considered as a chronic low-grade inflammatory state due to adipose tissue inflammation and is accompanied by secretion of certain proinflammatory cytokines, subsequent systemic inflammation are observed, subsequently, insulin resistance, increasing risk of type2 diabetes. The aim of the current study was to investigate the impact of weight loss following laparoscopic sleeve gastrectomy (LSG ) on type2 diabetes and blood cytokines in morbidly obese people.\n\nMaterials and Methods: Thirty five patients diagnosed as morbidly obese were included. Serum samples were collected from patients preoperatively and 4 months postoperatively to determine the levels of FBS ,HbA1C , tumor necrosis factor α (TNF-α), interleukine 6 (IL-6), interleukine 1β (IL-1β), and interleukine 10 (IL-10) using enzyme-linked immunosorbent assay (ELISA).\nResults: Four months following operation BMI reduction and weight loss were proven. with decrease levels of FBS, HbA1C with resolution of diabetes in 28 patients.\n Also a significant decrease in serum levels of the proinflammatory cytokines, TNF-α, IL-6, and IL-1β, was observed 4 months postoperatively. On the other hand, the level of the anti-inflammatory IL-10 cytokine was significantly increased in the serum of postoperative patients when compared to preoperative ones. Conclusion: It can be concluded that weight loss following LSG was accompanied by decrease levels of FBS, HbA1C with resolution of diabetes and decrease of the serum proinflammatory cytokines and an increase of the anti-inflammatory cytokine, which led to improvement of the inflammatory response of morbidly obese people.
Saemaul Movement policy was initiated in Korea in the 1970s and has continued to be implemented up until today, though its targets and focuses have changed to a certain extent in the intervening time, reflecting changing conditions in Korea. Today, the policy is eliciting a great deal of attention from international organizations, which see it as a potentially good development model for less advanced countries. In particular, international organizations such as the UN, the OECD, and the Asian Development Bank have appreciated it as being a successful rural development policy applicable to other countries, and have called for it to be researched further and to be disseminated among less developed countries. Against this background, this article attempts to explore the ways in which the policy might effectively be transferred to other countries, and seeks to put forward suggestions beneficial to policymakers and practitioners involved with the policy in Korea. In doing so, this research employs the Qualitative Comparative Analysis (QCA) method to discover the conditions affecting the successful transfer of the Saemaul Movement policy.
The study examines the association between soft skills, well-being at work and employability,\ncontributing to the construction of program development of soft skills and support\nemployability in higher education. It was administered the questionnaire intrapersonal skills,\ninterpersonal and professional (Jardim & Pereira, 2004), inventory of employability (Duarte\n& Fraga, 2009), the scale of well-being at work (Santos & Gonçalves, 2010) and the\nsociodemographic questionnaire (Oliveira & Costa Lobo, 2013) to 53 male students aged\nbetween 18 and 53 years of computer science at the University Portucalense Infante D.\nHenrique in the academic year 2013/2014. Through the causal-comparative analysis, it was\nfound that students with work experience have a higher level of employability and well-being\nat work. By Spearman correlation, it was established that cooperation and self-fulfillment are\nlinked to employability. It was found that employability and well-being at work are related\npositively and significantly.
Telomeres are nucleotides that define destiny of eukaryotic cells and their cellular function which gets adapted in response to various stimuli. They are known to provide stability to chromosomes and protect DNA from degradation. Shortening of telomere length due to genetic, physical, chemical or epigenetic factors exacerbate cell’s fate, inducing aging. Review of literature shows significant contribution of telomere length in the process of aging and age related diseases like type II diabetes, cardio vascular diseases (CVD) etc. It is well documented that shortening of telomeres leads to cell senescence engendering detrimental effect on longevity of individuals. Dynamics of telomere length also show a decrease in the immune response causing immune aging. Decrease in telomerase and alternate lengthening of telomere (ALT) activities are other important contributing factors for age associated disorders. The activity of telomerase and ALT also commandeer vast majority of cancers. Oxidative stress had also been shown to impose a profound effect on the shortening of telomere length predisposing the individual to disease morbidity and mortality. Recent information regarding the telomeropathies provides a challenging opportunity to study the impact of telomere length on the course of disease. The present review is an attempt to provide comprehensive information regarding the telomere length, telomerase and the probable mechanisms involved within different tissues associated with aging.