Since the late 1990s, the topic of sexual assistance for people with disabilities has garnered substantial attention at an international level, becoming a focal subject of numerous studies and investigations. Scholars such as Earle (1999), Tepper (2000), Shakespeare (2000), and Waxman Fiduccia (2000) have highlighted the pervasive taboos and silence surrounding sexuality and disability. In recent years, this intersection has emerged as a significant issue of social justice, as emphasized by Shuttleworth (2007). The perspective has shifted from a predominantly medical viewpoint to a more inclusive social and cultural framework (Tepper, 2000). This study endeavors to integrate pedagogical insights with findings from sociological, psychological, and political research to elucidate the role of the sexual assistant, which is receiving increased legislative attention in Italy. A recent bill aims to regulate this role to promote 'healthy sexuality and psycho-physical well-being of people with disabilities' (Parliamentary Acts, n. 1442, 9 April 2014), mirroring regulations in other European nations. The study proposes a comprehensive sex education model for individuals with disabilities, reflecting on socio-cultural, political, and pedagogical dimensions. The research culminates in project guidelines informed by pedagogical literature (Mannucci, 2002; Gelati & Malignano, 2003; Castelli & Mariani, 2005; Goussot, 2008; Lascioli, 2013; Castelli, Cereda, Crotti, Villa, 2013).

Randomized controlled trials have indicated similar bleeding rates for dabigatran, rivaroxaban, and warfarin. This study aims to evaluate the real-world incidence of bleeding in patients with atrial fibrillation (AF) initiating treatment with these anticoagulants. Using a comprehensive computerized database, we identified patients who began receiving dabigatran, rivaroxaban, or warfarin over a three-year period. Bleeding events that required hospitalization were meticulously reviewed, and bleeding incidences were calculated per 100 patient-years of treatment. Our study included 18,249 patients: 9,564 (52.4%) on warfarin, 5,976 (32.7%) on dabigatran, and 2,709 (14.8%) on rivaroxaban. The bleeding incidences were 3.9 for warfarin, 4.2 for dabigatran, and 4.1 for rivaroxaban. Intracranial hemorrhage rates were 0.71 for warfarin, 0.4 for dabigatran, and 0.27 for rivaroxaban. Gastrointestinal hemorrhage rates were 1.88 for warfarin, 2.98 for dabigatran, and 2.39 for rivaroxaban. These findings align with RCTs, confirming similar bleeding risks among the three treatments in a real-world setting.

The concept of ecological infrastructure, which can serve as a foundational element for sustainable development, was introduced by A. Tetior in 2003. This infrastructure encompasses a wide range of urban, regional, global, and cosmic elements, both natural and man-made, that support the environmentally sustainable preservation of human habitats. The system includes frameworks of knowledge, actions, and decisions aimed at maintaining the resilience of socio-ecological systems, promoting ecological education, conserving living environments, and fostering ecological balance. By reducing the negative impacts of human activities on natural ecosystems, increasing resource efficiency, and prioritizing renewable resources, ecological infrastructure facilitates a gradual transition to negentropy technologies. This approach offers a more pragmatic pathway to creating high-quality environments, potentially replacing the less feasible concept of traditional sustainable development.

The Areopa Group, renowned for its expertise in Intellectual Capital Accounting and Applied Knowledge Management, has developed innovative systems to quantify intangible assets monetarily. With over 40,000 man-days dedicated to R&D, the group has devised an IC Calculation system that evaluates 77 intangible assets using econometrics. Complementary systems for IC Accounting and IC Auditing align with IAS/IFRS standards, ensuring comprehensive evaluation of IC balance sheets. Additionally, methodologies for capturing, storing, and re-utilizing tacit and explicit knowledge have been established, transforming these insights into organizational assets. This research has the potential to revolutionize business processes, offering unique licensing models for market application. The paper delves into these systems' intricacies, presenting a transformative approach to organizational knowledge and asset management.

This paper presents a method of converting color images of histopathological slides to grayscale as a preprocessing step for image segmentation. The method utilizes the characteristics of these images to minimize information loss during conversion. It employs a global mapping scheme ensuring that the same color does not map to two different grayscale values. By adding color information to brightness, the method reduces information loss, with weights for the added color depending on pixel distribution in the images. The technique was tested on a large set of histopathological slide images, yielding convincing results, some of which are published herein.

This study investigates the impact of a computer game-based intervention designed to alleviate symptoms of Attention Deficit Disorder (ADD) in children with various special needs. The sample comprised 30 primary school children from Jeddah, Saudi Arabia, divided equally into three categories: those with learning disabilities, deafness, and mild mental retardation. Participants were assessed using the DSM-IV-TR® criteria for ADD and further evaluated by the electronic attention disorder scale, known as the Alert Test. The intervention was implemented over a specified period, during which the experimental group engaged in structured computer game activities tailored to enhance attention and cognitive functioning. Post-intervention analysis revealed significant improvements in attention among children across all categories, as evidenced by their post-test scores. These findings suggest that computer game programs could serve as effective tools in managing ADD symptoms in children with special needs, highlighting their potential for broader application in educational settings.