Background: The analgesic antipyretic drug acetaminophen (Paracetamol; PCM) utilized in the treatment of inflammatory disorders has been found to induce liver and renal disorders in both animals and humans. Its administration in a high dose causes hepatic and renal toxicities and results in hepato-renal cell deaths by activating multiple stress pathways. Objectives: This study was conducted to investigate and compare the effects of Sidr honey (SH) and Nigella sativa oil (NS) and the effect of their combined use on the paracetamol (PCM)-induced hepato-renal toxicities in rats. Study design: Forty male adult albino rats were divided into five groups and treated for 4 weeks (n= 8 each): (1) the normal control group; receiving distilled water orally, (2) PCM-treated (SHDP); receiving single high dose PCM of 1 g/kg once orally, (3) concomitant NS- and PCM-treated (NS/P); receiving NS in the dose of 2 ml/kg/day orally, and at the end of NS-treatment, the same single PCM dose is given, (4) concomitant SH- and PCM-treated (H/P); receiving SH in the dose of 1 g/kg/day, and at the end of SH-treatment, the same PCM dose is given, (5) concomitant SH-, NS- & PCM-treated (H&NS;/P) group; receiving SH and NS orally in the same doses, and at the end of treatments, the same PCM dose is given. Serum alanine transaminase (ALT), aspartate transaminase (AST), blood urea nitrogen (BUN), creatinine, total antioxidative capacity (TAC) and Fas ligand (Fas L), and liver tissue TAC were measured after sacrificing the rats at the end of experiment. Results: Compared to control group, the SHDP-treated rats developed significant increases in serum ALT, AST, BUN, Creatinine and Fas l, and decreases in serum and liver tissue TAC. SH, NS or more effectively the combined H/NS/P treatments produced significant decreases in serum ALT, AST, BUN, Creatinine and Fas l, and increases in serum and liver tissue TAC when compared with SHDP-treated rats. Conclusion: These findings suggested that oral combined SH and NS administration is more protective against PCM-induced hepato-renal toxicity in rats than using each of them alone. The collective data demonstrated that SH and NS have considerable ability to protect against oxidation, apoptosis, and other harmful effects of PCM in rats.
Face recognition is more advantageous than other biometric systems such as signature, iris scanning, fingerprint, etc. It can apply without cooperation of individuals. Effect of illumination, partial occlusion and different imaging conditions makes face recognition more complex problem. Preposed work demonstrates designing, implementation and verification of a face recognition system under partial occlusion conditions. Face recognition process is composed of image acquisition, face components detection, feature extraction, face recognition and identification of person name. Facial components such as left eye, right eye, nose and mouth are detected with separate detectors developed for every facial component. After the facial components extraction histogram equalization, resizing and vectorizing operations are applied. Feature selection approach is used in proposed technique. Principal component analysis (PCA) is used for feature selection and 1033 features are selected for recognition purpose. First select 2016 features out of 2520. Then select 1613 features from 2016. Finally select 1033 features from 2016 features. Then FeedForward Neural Network is used for classification purpose. MATLAB environment is used for the face recognition process. The experiments were performed on AR face database.
Wood deterioration and degradation are a crucial process on earth which it will promote the recycling of organic and inorganic materials. These process, however, also destroy wooden monuments that have been used as sculpture and historic building resulting aesthetic and structural damage. In recent years, microbial deterioration and degradation present in many historic and significant objects have attracted the particular attention of the archaeologist and microbiologist. The aim of our study was to examine the diversity of microbial communities responsible for the deterioration of the wooden archaeological artworks which built in 7000 cal. BP. For this purpose, the clone library of fungi and bacteria was constructed and 18 microbial strains were isolated and identified from Kuahuqiao and Tianluoshan site. The clone library showed that bacterial diversity was represented by different bacterial phylum such as Proteobacteria, Actinobacteria, Firmicutes, Bacteroidetes, Fibrobacteres. However, Firmicutes was detected to be the predominant bacterial communities of three samples, accounted for 30.12%. In addition, 15 isolated strains were used to detect their abilities to degrade wood and synthetic polymers commonly present in artworks as protective materials. The results indicated few of bacteria and fungi could produce esterase, lipase, endocellulase and ligninase, which may be involved in deterioration of wooden artwork’s structure and protective materials. This is the first time that we carry out study on the detection of microbial distribution in Kuahuqiao and Tianluoshan site. Our investigations provide new information on the potential microbial inhabitants of wooden artworks and synthetic materials.
Considering the impact of the non-linear stiffness dynamic non-linear vibration model with cubic terms was established according to the structural feature and non-linear behavior of the tracked ambulance. In this paper is vibration control of the main system using control at the simultaneous primary and internal resonance , the multiple scale perturbation method is applied to obtain a solution up to the second order approximations. Other different resonance cases are reported and the effects of different parameters are studied numerically. The stability of the system is studied using frequency response curves and phase plane. Comparison between numerical solution and the approximate solution is obtained.
Background. There are differences between the results of studies performed in different centres, regarding the substances responsible for anaesthetic related anaphylaxis. Anaphylaxis due to colloid plasma expanders is a recognized but rare life-threatening complication in patients.\n\nMethods. For 5 years (January, 2009-June, 2013) the patients presenting with perianaesthetic anaphylaxis were analyzed in the Pomeranian area in Poland. The diagnosis was based on case history, skin prick and intradermal tests, specific IgE measurement and serum mast cell tryptase. Reactions were defined as IgE-mediated (anaphylactic-type), if positive skin tests, and/or specific IgEs occur.\n\nResults. Out of 25 referred patients(18 females, 7males, ages ranging between 22 and 67) 5 consented to complete all investigations needed for identifying the gelafusin of the allergic reaction. An IgE mediated mechanism was confirmed in 100% patients. \n\nConclusion. In the all of the 5 cases an IgE mediated mechanism was identified. Patients with suspected allergic reactions during anaesthesia should be referred for investigation in specialist centres whenever possible.