Vol. 20, Issue 10
Section 1
ID: qrVSF
Franziska M. Bergmann, Li Zhi-Hua, Arun K. Mehta
Keywords: Department of Molecular Biology, University of Heidelberg, Germany; Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, China; Department of Biotechnology, Indian Institute of Technology Delhi, India
The dynamic regulation of gene expression is fundamental to understanding cellular processes in eukaryotic organisms. This study investigates the temporal patterns of transcriptional regulation in response to environmental stimuli. Using a combination of chromatin immunoprecipitation sequencing (ChI...
Vol. 20, Issue 10
Section 1
ID: GxhaM
Johannes M. Fischer, Nandini R. Patel, Chul-Woo Park
Keywords: Department of Bioinformatics, University of Heidelberg, Germany; Department of Computational Biology, Indian Institute of Science, India; School of Computer Science and Engineering, Seoul National University, South Korea
Protein structure prediction remains a pivotal challenge in computational biology, crucial for understanding biological processes and drug discovery. This study aims to advance protein structure prediction accuracy using a novel neural network architecture. We employed a hybrid machine learning mode...
Vol. 20, Issue 10
Section 1
ID: 3t3Ja
Annika M. Schroeder, Arjun N. Patel, Han Mei-Ling
Keywords: Institute of Developmental Biology, University of Bonn, Germany; Department of Biological Sciences, Indian Institute of Science, Bengaluru, India; School of Life Sciences, Tsinghua University, Beijing, China
Morphogenesis is a critical aspect of developmental biology, orchestrating the spatial and temporal patterns that shape the growth of tissues and organs. This study investigates the role of Hedgehog (Hh) signaling in vertebrate limb morphogenesis, focusing on its spatial and temporal dynamics. Utili...
Vol. 20, Issue 10
Section 1
ID: 9Dzbt
Stefan Müller-Lange, Rin Chen-Wei, Kofi Osei-Adomako
Keywords: Department of Ecology, University of Freiburg, Germany; Department of Environmental Science, Tsinghua University, China; Department of Ecology and Environmental Sciences, University of Ghana, Ghana
Understanding the adaptive strategies of temperate forest species to climate variability is crucial in the context of increasing global climate change. This study aims to investigate the physiological and ecological responses of key temperate forest species in the Northern Hemisphere. We employed a ...
Vol. 20, Issue 10
Section 1
ID: b7FyM
Hans-Günter M. Schnabel, Li Na-Mei, Priya R. Swaminathan
Keywords: Department of Molecular Biology, Max Planck Institute for Biochemistry, Germany; School of Life Sciences, Peking University, China; Department of Cellular and Molecular Biology, Indian Institute of Science, India
Autophagy plays a critical role in cellular homeostasis by mediating the degradation and recycling of cellular components. The objective of this study was to explore the specific roles of Atg proteins in the autophagy pathway. Utilizing CRISPR-Cas9 gene editing, we generated Atg-deficient cell lines...
Vol. 20, Issue 10
Section 1
ID: mPtA2
Bernhard F. Vogel, Kimura Aiko, Manoj K. Iyer
Keywords: Department of Genetics, University of Heidelberg, Germany; Department of Biological Sciences, University of Tokyo, Japan; Department of Genomic Sciences, Indian Institute of Science, Bangalore, India
Island populations often exhibit unique genetic characteristics due to their isolation and distinct environmental pressures. This study aims to analyze the genetic diversity and adaptive potential within isolated island populations, using a comparative approach between island and mainland groups. We...