Mamdouh I. Nassar, Mohammed Zayed
The study investigates the bioactivity of various drugs and phenylazo compounds, along with their copper (II) and nickel (II) complexes, on the flour beetle Tribolium confusum. Adult beetles were exposed to different dosages of ibuprofen, naproxen, lornoxicam, and indomethacin, as well as phenylazo compounds. Results indicated significant biological effects, with increased mortality rates corresponding to higher dosages. Lornoxicam showed a 73% mortality rate at a 50µg dose, while its combination with Cu (II) ions resulted in lower mortality. In contrast, ibuprofen combined with Cu (II) ions achieved an 86% mortality rate compared to 41% without the ions. Phenylazo compounds R1 and R2 showed enhanced bioactivity when complexed with metal ions, while compounds R3 and R4 showed decreased effects. Notably, compound R3 achieved 100% mortality at a 30µg dose. This research concludes that these compounds, along with their metal complexes, could serve as effective bioactive agents against pests.