Synthesis, Investigation of New Dihydropyrimidine Derivatives and Their Biological Activity

We report the synthesis and investigation of new biologically active derivatives of dihydropyrimidines, specifically compounds 2 and 3. Detailed NMR spectroscopy experiments reveal the presence of diastereomers and tautomers in these compounds. Compound 2 displays signal splitting into doublets and multiplets, confirming diastereomer presence. For compound 3, both diastereomers and tautomers are observed in solution. An individual diastereomer of compound 3 was successfully isolated. The biological activity of these synthesized compounds was evaluated against various species of the genus Aspergillus fungi, demonstrating significant potential for antifungal applications.