Essam F. Al-Jumaily, Saja Matheel Fakhri
Bauhinia variegata L., a member of the Leguminosae family, has been traditionally used for its antidiabetic properties. This study investigates the hypoglycemic and hypolipidemic effects of petroleum ether and methanol extracts from the leaves and flowers of Bauhinia variegata in alloxan-induced diabetic mice. Concentrations of 200 and 400 mg/kg of leaf extracts (LM1 and LM2) and 200 mg/kg of flower extracts (F) were administered intraperitoneally for 10 days. Serum biochemical parameters, including glucose, cholesterol, triglycerides, HDL, LDL, and VLDL, were measured. Histopathological analysis of liver and pancreas tissues was conducted post-treatment. Results indicated a dose-dependent reduction in blood glucose levels, suggesting the potential of Bauhinia variegata extracts as a non-toxic treatment for diabetes.