Yasir Mehmood, Humayun Riaz, Kashif Barkat, Hammad Yousaf, Syed Atif Raza
The objective of this study was to develop polymeric microspheres utilizing sulfasalazine and dexamethasone with okra gum and hydroxypropyl methylcellulose (HPMC). Recent advancements in microsphere technology, including patents on nanocapsule formulations, informed the selection of drug and polymer combinations. The microspheres were formulated using a solvent extraction technique, and their efficacy was assessed through various analytical methods. Fourier-transform infrared spectroscopy (FTIR) revealed no significant interactions between the drugs and polymers, while differential scanning calorimetry (DSC) confirmed molecular dispersion within the microspheres. Dissolution studies demonstrated an extended drug release up to 8 hours when utilizing the combined polymers compared to their individual use. The findings suggest that the concentrations of Okra gum and HPMC significantly impact the recovery, entrapment efficiency, hydration, and drug loading of the microspheres. The study concludes with the successful preparation of Okra gum/HPMC microspheres, emphasizing their potential in sustained drug delivery systems.