Vol. 20, Issue 3
2026
ID: QmrBK
Ingrid J. Müller, Chen Liang-Zhi, Thandeka Ndlovu
Understanding the precise mechanisms by which enzymes achieve catalysis is crucial for advancements in biochemistry and drug design. This study focuses on the allosteric regulation of catalytic triads in serine proteases, enzymes that play a vital ro...
Vol. 20, Issue 1
2026
ID: a4ULT
Hans-Peter Müller, Li Ming-Hu, Priya N. Iyer
The allosteric regulation of AMP-activated protein kinase (AMPK) plays a pivotal role in cellular energy homeostasis, making it a critical target for therapeutic intervention in metabolic disorders. Despite extensive study, the detailed structural me...
Vol. 19, Issue 10
2025
ID: F8Xvk
Hannes F. Müller, Aditi R. Nair, Zhang Min-Jie
The intricate process of RNA splicing is crucial for the generation of mature messenger RNA (mRNA), yet the influence of small nuclear RNA (snRNA) modifications on splicing efficiency remains poorly understood. This study aims to explore the impact o...