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Found 14 articles for "University of Tokyo"
Bacterial pathogenesis, particularly the interaction between Vibrio cholerae and its human host, remains a critical area of study due to its global health implications. This study aims to elucidate the molecular mechanisms underlying V. cholerae-indu...
The advent of high-throughput genomic technologies has provided an unprecedented opportunity to explore the intricate relationships between genetic variations and environmental factors in the manifestation of complex traits. This study aims to elucid...
Biodiversity loss in fragmented landscapes poses significant challenges to conservation efforts. This study explores adaptive management strategies to enhance ecological connectivity and improve habitat quality for threatened species. Our objective w...
The integration of machine learning algorithms into computational biology has transformed the way cellular dynamics are understood and modeled. This study aims to develop a robust predictive framework for cellular interactions using an integrative ma...
The process of protein folding is crucial for understanding many biological functions and dysfunctions, yet its detailed mechanisms remain elusive. This study aims to explore the kinetics of protein folding using a combination of experimental and com...
The sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA1a) is essential for muscle function, mediating calcium transport across the sarcoplasmic reticulum membrane. Understanding the conformational states of SERCA1a during ATP binding and hydrol...
Hereditary retinal degenerations represent a leading cause of blindness with genetic defects that affect millions globally. This study aimed to explore novel gene therapy strategies to address these debilitating conditions. We employed adeno-associat...
The increasing prevalence of environmental stresses such as drought and salinity necessitates the development of crops with enhanced stress tolerance. This study aims to investigate the role of specific genes in stress tolerance by utilizing CRISPR-C...
Protein folding is a fundamental process essential for cellular function, and its misregulation is linked to numerous diseases. This study investigates the influence of chaperone proteins on protein folding dynamics, seeking to provide insights into ...
The rapid evolution of viruses presents significant challenges to public health, primarily due to their ability to adapt quickly via mutation. This study investigates the adaptive mechanisms within RNA viruses, focusing on mutation dynamics and their...
The complexity of plant immunity lies in its ability to integrate various signaling pathways to mount an effective defense response. This study aims to dissect the cross-talk mechanisms among key signaling pathways in plant immunity using Arabidopsis...
Organelle dynamics are critical to cellular homeostasis and adaptation to stress. This study investigates the mechanisms underlying mitochondrial redistribution in response to cellular stress in mammalian cells. We aimed to elucidate the role of cyto...
Understanding the intricate interactions within neural circuits is critical for deciphering the complex functionalities of the brain. This study aims to explore the dynamic properties of cortical microcircuits, focusing on synaptic plasticity and inf...
Neurodegenerative diseases like Alzheimer's disease (AD) are characterized by progressive synaptic loss and cognitive decline. Understanding the molecular underpinnings of synaptic vulnerability in AD is crucial for developing effective therapies. Th...