Table of Contents

Research Articles

1

Elucidating Cross-Talk Mechanisms in Plant Immune Signaling Pathways

Katrin E. Müller, Yuko Sato, Andrés M. Pérez

Institute of Plant Sciences, University of Freiburg, Germany; Department of Biological Sciences, University of Tokyo, Japan; Departamento de Biología, Universidad Nacional de Córdoba, Argentina

Keywords: plant immunity, Arabidopsis thaliana, signaling pathways, CRISPR-Cas9, transcriptomics, salicylic acid, jasmonic acid, ethylene

The complexity of plant immunity lies in its ability to integrate various signaling pathways to mount an effective defense response. This study aims to dissect the cross-talk mechanisms among key sign...

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2

Elucidating the Mechanisms of Self-Antigen Recognition in Autoimmune Disorders

Hans-Jürgen Müller, Kim Soo-Jin, Leila Haddad

Department of Immunology, Charité - Universitätsmedizin Berlin, Germany; Department of Immunology, Seoul National University College of Medicine, South Korea; Department of Immunology, American University of Beirut, Lebanon

Keywords: autoimmune diseases, self-antigen recognition, T-cell receptors, cytokines, systemic lupus erythematosus, rheumatoid arthritis

Autoimmune diseases are characterized by the immune system's aberrant response to self-antigens, leading to tissue damage and chronic inflammation. Despite extensive research, the precise mechanisms u...

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3

Integrative Network Analysis Enhances Predictive Modeling in Genomic Studies

Levent Ozdemir, Hiroshi Nakamura, Aditi Raghavan

Department of Computational Biology, Bogazici University, Istanbul, Turkey; Department of Bioinformatics, Kyoto University, Kyoto, Japan; Department of Systems Biology, Indian Institute of Science, Bangalore, India

Keywords: Predictive modeling, Genomic analysis, Network integration, Gene expression, Protein interaction, Epigenomics, Cancer genomics

The rapid advancement in genomic technologies has generated vast amounts of data, necessitating sophisticated computational techniques for analysis. This study aims to enhance predictive modeling in g...

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4

Elucidating the Allosteric Mechanisms in Human AMPK Through High-Resolution Cryo-EM Studies

Hans-Peter Müller, Li Ming-Hu, Priya N. Iyer

Department of Structural Biology, Max Planck Institute of Biochemistry, Germany; Department of Biochemistry, Peking University, China; School of Life Sciences, University of Hyderabad, India

Keywords: AMP-activated protein kinase, cryo-electron microscopy, allosteric regulation, molecular dynamics, phosphorylation sites, metabolic disorders

The allosteric regulation of AMP-activated protein kinase (AMPK) plays a pivotal role in cellular energy homeostasis, making it a critical target for therapeutic intervention in metabolic disorders. D...

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5

Characterizing Neural Network Dynamics Using Advanced fMRI Techniques in Cognitive Processing

Lars M. Kaufmann, Min-Jae Lee, Sofia R. Hernandez

Department of Neuroscience, Humboldt University of Berlin, Germany; Department of Brain and Cognitive Sciences, Seoul National University, South Korea; Instituto de Neurociencias, Universidad Nacional Autónoma de México, Mexico

Keywords: fMRI, cognitive processing, neural networks, brain connectivity, dynamic causal modeling, independent component analysis, prefrontal cortex

Understanding the dynamics of neural networks involved in cognitive processing is critical for advancing our knowledge of brain function. This study aims to employ advanced functional magnetic resonan...

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6

Adaptive Mechanisms in Viral Evolution: Insights from RNA Virus Mutation Dynamics

Hiroshi Nakamura, Priya S. Menon, Ahmed El-Mansouri

Department of Virology, University of Tokyo, Japan; Department of Microbial Genetics, Indian Institute of Science, Bangalore, India; Department of Molecular Biology, Cairo University, Egypt

Keywords: RNA virus, mutation dynamics, viral evolution, genetic recombination, genomic surveillance, replication fidelity

The rapid evolution of viruses presents significant challenges to public health, primarily due to their ability to adapt quickly via mutation. This study investigates the adaptive mechanisms within RN...

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7

Exploring the Role of Chaperone Proteins in the Dynamics of Protein Folding Pathways

Hiroshi Masuda, Fatima El-Sayed, Kumiko Nishimura

Department of Biophysics, University of Tokyo, Japan; Department of Molecular Biology, Cairo University, Egypt; Department of Structural Biology, Kyoto University, Japan

Keywords: protein folding, chaperone proteins, molecular dynamics, Hsp70, protein homeostasis, misfolding, therapeutic strategies

Protein folding is a fundamental process essential for cellular function, and its misregulation is linked to numerous diseases. This study investigates the influence of chaperone proteins on protein f...

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