Vol. 20, Issue 5
Section 1
ID: LFVm4
Lars van der Zwaal, Meera Srinivasan, Hu Zhi-Lin
Keywords: Department of Molecular Cell Biology, Leiden University, Netherlands; Department of Biochemistry, Indian Institute of Science, Bangalore, India; Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
Cell signaling via epidermal growth factor (EGF) is a critical process in regulating cellular proliferation, differentiation, and migration. The objective of this study was to elucidate the intricate crosstalk between EGF-initiated signaling pathways in human epithelial cells. Using advanced proteom...
Vol. 20, Issue 5
Section 1
ID: vCw3V
Matthias J. Neumann, Xiao Liu-Yang, Priya N. Kapoor
Keywords: Department of Immunology, Charité – Universitätsmedizin Berlin, Germany; Institute of Biochemical Engineering, Tsinghua University, Beijing, China; Department of Biotechnology, Indian Institute of Technology, Bombay, India
The rapid development of vaccines during the COVID-19 pandemic has highlighted the potential of mRNA-lipid nanoparticle (LNP) platforms in immunology. This study aims to explore the efficacy and safety of novel mRNA-LNP systems in eliciting immune responses. We synthesized and characterized LNPs enc...
Vol. 20, Issue 5
Section 1
ID: FpXxb
Sven J. Muller, Priya Patel, Li Wei-Hong
Keywords: Department of Developmental Biology, Max Planck Institute for Stem Cell Research, Germany; Department of Biological Sciences, Indian Institute of Science, India; School of Life Sciences, Peking University, China
Organogenesis is a critical phase of embryonic development whereby specific organs form from a relatively undifferentiated mass of cells. Our study focuses on elucidating the genetic and molecular pathways involved in lung organogenesis using zebrafish as a model organism. Zebrafish provides an idea...
Vol. 20, Issue 5
Section 1
ID: cfa7g
Sven Eriksson, Li Mei-Yun, Fatima Al-Mansouri
Keywords: Department of Molecular Biosciences, Stockholm University, Sweden; Institute of Molecular Biology, Tsinghua University, Beijing, China; Department of Biochemistry, King Saud University, Riyadh, Saudi Arabia
RNA processing, particularly the splicing of precursor mRNA, is a critical step in gene expression regulation. This study investigates the role of small nuclear ribonucleoproteins (snRNPs) in the splicing mechanisms of eukaryotic cells. Utilizing a combination of cryo-electron microscopy and genetic...
Vol. 20, Issue 5
Section 1
ID: aYBCk
Felix J. MĂĽhlberg, Mei-Li Zhang, Priya N. Iyer
Keywords: Department of Computational Biology, University of Heidelberg, Germany; School of Bioinformatics, Tsinghua University, China; Department of Computer Science, Indian Institute of Technology Madras, India
The advancement of machine learning techniques offers significant potential in the field of computational biology, particularly in genomic prediction modeling. This study aims to integrate sparse genomic datasets using neural network architectures to improve predictive accuracy in genomic studies. W...
Vol. 20, Issue 5
Section 1
ID: 8rEs2
Lena M. Schuster, Chen Ming-Hao, Adebayo Oluwaseun
Keywords: Lena M. Schuster; Department of Cognitive Neuroscience, University of Freiburg, Germany; Chen Ming-Hao; Department of Biomedical Engineering, Tsinghua University, China; Adebayo Oluwaseun; Department of Neurology, University of Lagos, Nigeria
The neural basis of cognitive decline with aging remains a critical area of research within neuroscience. This study investigates the alterations in functional connectivity of brain networks associated with working memory across different age groups. Using resting-state functional magnetic resonance...
Vol. 20, Issue 5
Section 1
ID: FRzVE
Liu Mei-Hua, Arne Müller, Carlos J. Velázquez
Keywords: Department of Botany, Peking University, China; Institute of Plant Sciences, University of Göttingen, Germany; Instituto de BiologĂa Molecular y Celular de Plantas, Universidad PolitĂ©cnica de Valencia, Spain
The development of plant organs such as leaves is a complex process orchestrated by multiple phytohormones, among which auxin plays a critical role. This study aims to investigate the influence of auxin gradient formation on leaf morphogenesis in Arabidopsis thaliana. Using a combination of genetic,...