Gut Microbiome Composition and Its Impact on Immune System Development

The gut microbiome plays a crucial role in shaping immune system development during early life. This study investigates the relationship between microbial colonization patterns and immune cell maturation in a cohort of 500 infants followed from birth to age three. Our findings reveal critical windows during which specific bacterial taxa influence T-cell differentiation and antibody production. We also identify dietary factors and environmental exposures that significantly impact microbiome composition and subsequent immune function.