Y. Jagannadham, B. Ramadevi, B. Prasanna
The title compounds, substituted 1H-benzo[f]chromen-3-yl-2H-chromen-2-ones, were synthesized via a one-pot reaction involving 3-aryl-1-(3-coumarinyl)propen-1-ones and 2-naphthol, catalyzed by DBU and concentrated H2SO4. The resulting products were obtained in ample yields and characterized using IR, 1H, and 13C NMR, as well as mass spectrometry and elemental analysis. The synthesized compounds were assessed for their in vitro antibacterial activity against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, and antifungal activity against Aspergillus niger and Candida albicans using the serial broth dilution method. Notably, compounds 3b and 3c exhibited significant antimicrobial results, highlighting their potential as therapeutic agents.