Grazyna Michalska-Krzanowska
Background: Anaphylaxis during anesthesia is a critical event that can be triggered by various substances, including colloid plasma expanders like Gelofusine. Although rare, these reactions can be life-threatening and require thorough investigation. Methods: Over a five-year period (January 2009-June 2013), we analyzed cases of perianaesthetic anaphylaxis in the Pomeranian region of Poland. The study involved a detailed examination of patient history, skin prick and intradermal tests, specific IgE measurements, and serum mast cell tryptase levels. An IgE-mediated mechanism was confirmed through positive skin tests and/or specific IgEs. Results: Among 25 referred patients (18 females, 7 males, aged 22 to 67), five completed all necessary investigations identifying Gelofusine as the allergen. An IgE-mediated mechanism was confirmed in all cases. Conclusion: Our findings underscore the importance of referring patients with suspected anaphylactic reactions during anesthesia to specialized centers for accurate diagnosis and management.