Vol. 20, Issue 2
Section 1
ID: YrXGQ
Marta J. van der Meer, Takashi Inoue, Arjun Kumar
Keywords: Department of Environmental Sciences, Utrecht University, Netherlands; Department of Botany, Kyoto University, Japan; Department of Ecology, Indian Institute of Science, Bangalore, India
Climate change poses a significant threat to global biodiversity, particularly in sensitive alpine ecosystems. This study investigates how genetic diversity within plant species contributes to their ability to adapt to changing climatic conditions. Our objective was to evaluate the genetic variation...
Vol. 20, Issue 2
Section 1
ID: LfjXX
Konrad F. Müller, Kimiko Sato, Vikas N. Patel
Keywords: Department of Plant Molecular Biology, University of Bonn, Germany; Department of Biological Sciences, University of Tokyo, Japan; Department of Biotechnology, Indian Institute of Technology Bombay, India
The increasing prevalence of environmental stresses such as drought and salinity necessitates the development of crops with enhanced stress tolerance. This study aims to investigate the role of specific genes in stress tolerance by utilizing CRISPR-Cas9 gene editing technology in the model plant Ara...
Vol. 20, Issue 2
Section 1
ID: ejSfh
Hans-Peter Müller, Min-Jae Lee, Fatima El-Sayed
Keywords: Department of Microbial Ecology, University of Tübingen, Germany; Department of Life Sciences, Seoul National University, South Korea; Department of Biology, American University of Beirut, Lebanon
The human gut microbiome plays a pivotal role in maintaining metabolic health, yet its diversity is influenced by various cultural and dietary factors. This study explores the relationship between microbiome diversity and metabolic health across different populations. We conducted a cross-sectional ...
Vol. 20, Issue 2
Section 1
ID: 3NXaB
Stefan J. Müller, Mei-Ling Hu, Rajiv N. Patel
Keywords: Department of Computational Biology, University of Heidelberg, Germany; Department of Bioinformatics, Peking University, China; Department of Biotechnology, Indian Institute of Technology Bombay, India
Protein structure prediction remains a pivotal challenge in computational biology, with significant implications for drug discovery and molecular biology. This study aims to enhance the accuracy of protein structure prediction by integrating deep learning techniques with evolutionary algorithms. We ...
Vol. 20, Issue 2
Section 1
ID: fDDKh
Helena K. Fischer, Sunil Bhattacharya, Zhao Ming-Wei
Keywords: Department of Molecular Biology, University of Heidelberg, Germany; Department of Biological Sciences, Indian Institute of Science, Bangalore, India; Institute of Cell and Molecular Biology, Tsinghua University, China
The dynamic interactions between organelles are crucial for maintaining cellular homeostasis and function. This study investigates the crosstalk between mitochondria and lysosomes, two vital organelles involved in energy metabolism and cellular waste disposal, respectively. Our objective was to eluc...
Vol. 20, Issue 2
Section 1
ID: jkbZ3
Dr. Arjun V. Desai, Li-Xiu Zhang, Prof. Miriam van der Hoek
Keywords: Department of Molecular Biology, Indian Institute of Science, Bangalore, India; Key Laboratory of Molecular Biology, Tsinghua University, Beijing, China; Division of Biochemistry, Leiden University, Leiden, Netherlands
DNA repair is critical for maintaining genomic integrity, with poly(ADP-ribose) polymerase (PARP) playing a pivotal role in the repair of DNA double-strand breaks (DSBs). This study aims to delineate the mechanisms by which PARP facilitates DSB repair through homologous recombination (HR) and non-ho...
Vol. 20, Issue 2
Section 1
ID: ph6BJ
Matthias P. Schneider, Linh Dao-Phuong, Tariq H. Al-Mansouri
Keywords: Department of Neuroscience, University of Munich, Germany; Institute of Brain Research, Vietnam National University, Hanoi, Vietnam; Department of Neurology, King Faisal University, Saudi Arabia
Synaptic plasticity is a cornerstone of neurobiological processes, essential for learning and memory formation. This study aims to elucidate the underlying mechanisms that govern synaptic plasticity through detailed examination of neuronal adaptation. We utilized advanced electrophysiological techni...
Vol. 20, Issue 2
Section 1
ID: xfp8s
Sven M. Jansen, Aria K. Patel, Li Wei-Hua
Keywords: Department of Biophysics, University of Amsterdam, Netherlands; Department of Molecular Biology, Indian Institute of Science, Bangalore, India; School of Life Sciences, Tsinghua University, Beijing, China
Understanding the dynamics of protein folding is crucial for elucidating the mechanisms underlying many biological processes and diseases. This study focuses on the role of hydrophobic interactions in the folding pathways of globular proteins. Using a combination of molecular dynamics simulations an...