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Found 14 articles for "Department of Biotechnology"
Understanding the complex process of protein folding is crucial for deciphering cellular functions and developing therapeutic strategies for protein-misfolding diseases. This study investigates the biophysical properties influencing the folding pathw...
Antibody engineering has significantly advanced the field of immunotherapy, providing novel approaches to enhance therapeutic efficacy against a variety of diseases. The objective of this study was to develop and optimize engineering techniques for a...
Pseudomonas aeruginosa is a prominent opportunistic pathogen responsible for severe infections, particularly in immunocompromised patients. The bacterium's ability to evade host immune responses is a significant factor in its pathogenicity. This stud...
Understanding the regulatory mechanisms of gene expression is pivotal in elucidating cellular responses to environmental stressors. This study focuses on the heat shock protein (HSP) gene expression in Drosophila melanogaster, a model organism in gen...
The increasing prevalence of environmental stresses such as drought and salinity necessitates the development of crops with enhanced stress tolerance. This study aims to investigate the role of specific genes in stress tolerance by utilizing CRISPR-C...
Protein structure prediction remains a pivotal challenge in computational biology, with significant implications for drug discovery and molecular biology. This study aims to enhance the accuracy of protein structure prediction by integrating deep lea...
Morphogenesis, the biological process that causes an organism to develop its shape, is a crucial aspect of developmental biology. This study aims to elucidate the integrative mechanisms underlying epithelial folding, a fundamental morphogenetic proce...
Organelle dynamics are critical to cellular homeostasis and adaptation to stress. This study investigates the mechanisms underlying mitochondrial redistribution in response to cellular stress in mammalian cells. We aimed to elucidate the role of cyto...
The complex interplay between the MAPK and PI3K/Akt signaling pathways plays a critical role in cellular processes such as proliferation, differentiation, and survival. Despite extensive research, the precise mechanisms of crosstalk remain elusive. T...
Stem cells possess the unique ability to differentiate into various cell types, rendering them crucial for regenerative medicine. The Wnt signaling pathway is pivotal in regulating stem cell fate, though its precise role in lineage specification rema...
Gene therapy has emerged as a promising approach for the treatment of monogenic disorders, leveraging advances in genome editing technologies. This study aims to evaluate the efficacy and safety of CRISPR-Cas9 mediated gene therapy in correcting gene...
Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) is a critical enzyme found in plants and autotrophic organisms such as microalgae and cyanobacteria. This study conducts an in silico evaluation to identify RuBisCO proteins from these organis...
Due to the sensitivity of potatoes to viruses, the production of virus-free plants is critical for reducing production costs and enhancing yield. This study evaluates the effect of eleven combined hormonal and vitamin treatments on the main and secon...
Obesity is a major public health challenge of the 21st century, while type 2 diabetes mellitus (T2DM) is one of the most widespread chronic diseases globally, contributing to escalating health burdens. Both obesity and overweight status elevate the r...