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Found 21 articles for "Tsinghua University"
The explosion of genomic data presents an unprecedented opportunity for the application of machine learning techniques in computational biology, particularly in oncology. The objective of this study was to develop a robust deep learning framework cap...
In the field of biomechanics, understanding how cells sense and respond to mechanical stimuli is crucial for elucidating the mechanisms underlying various physiological and pathological processes. This study investigates the mechanotransduction pathw...
Understanding enzyme mechanisms is crucial for advancing biochemical applications in medicine and industry. This study focuses on the catalytic triad mechanism in serine proteases, a pivotal group of enzymes involved in numerous physiological process...
The regulation of gene expression during early embryonic development is critical for proper cellular differentiation and organismal growth. This study investigates the transcriptional dynamics and underlying regulatory mechanisms of gene expression i...
Morphogenesis, the biological process that causes an organism to develop its shape, remains a focal point of developmental biology. This study explores the cellular and molecular mechanisms underlying vertebrate limb development, focusing on the dyna...
Proteomics is an essential tool in biochemistry, offering insights into protein function and interaction. Our study aims to advance proteomic profiling by exploring post-translational modifications (PTMs) across varying cellular environments. We empl...
The resurgence of infectious diseases necessitates the development of efficacious vaccines, with mRNA platforms offering a promising avenue. This study focuses on the integration of novel adjuvant formulations to enhance the immunogenicity of mRNA va...
The accurate prediction of protein structures is a cornerstone of computational biology, pivotal for understanding biological functions and designing therapeutics. Despite advances, current methods face challenges in balancing prediction accuracy and...
The rapid development of vaccines during the COVID-19 pandemic has highlighted the potential of mRNA-lipid nanoparticle (LNP) platforms in immunology. This study aims to explore the efficacy and safety of novel mRNA-LNP systems in eliciting immune re...
RNA processing, particularly the splicing of precursor mRNA, is a critical step in gene expression regulation. This study investigates the role of small nuclear ribonucleoproteins (snRNPs) in the splicing mechanisms of eukaryotic cells. Utilizing a c...
The advancement of machine learning techniques offers significant potential in the field of computational biology, particularly in genomic prediction modeling. This study aims to integrate sparse genomic datasets using neural network architectures to...
The neural basis of cognitive decline with aging remains a critical area of research within neuroscience. This study investigates the alterations in functional connectivity of brain networks associated with working memory across different age groups....
The rapid advancement in computational biology has opened new avenues for exploring protein-protein interaction (PPI) networks, particularly in cancer research. This study aims to elucidate the complexity of PPIs in oncogenesis and propose potential ...
Antibody engineering has significantly advanced the field of immunotherapy, providing novel approaches to enhance therapeutic efficacy against a variety of diseases. The objective of this study was to develop and optimize engineering techniques for a...
Understanding the precise mechanisms by which enzymes achieve catalysis is crucial for advancements in biochemistry and drug design. This study focuses on the allosteric regulation of catalytic triads in serine proteases, enzymes that play a vital ro...
The dynamic interactions between organelles are crucial for maintaining cellular homeostasis and function. This study investigates the crosstalk between mitochondria and lysosomes, two vital organelles involved in energy metabolism and cellular waste...
DNA repair is critical for maintaining genomic integrity, with poly(ADP-ribose) polymerase (PARP) playing a pivotal role in the repair of DNA double-strand breaks (DSBs). This study aims to delineate the mechanisms by which PARP facilitates DSB repai...
Understanding the dynamics of protein folding is crucial for elucidating the mechanisms underlying many biological processes and diseases. This study focuses on the role of hydrophobic interactions in the folding pathways of globular proteins. Using ...
The complex interplay between the MAPK and PI3K/Akt signaling pathways plays a critical role in cellular processes such as proliferation, differentiation, and survival. Despite extensive research, the precise mechanisms of crosstalk remain elusive. T...
Stem cells possess the unique ability to differentiate into various cell types, rendering them crucial for regenerative medicine. The Wnt signaling pathway is pivotal in regulating stem cell fate, though its precise role in lineage specification rema...
The intricate process of RNA splicing is crucial for the generation of mature messenger RNA (mRNA), yet the influence of small nuclear RNA (snRNA) modifications on splicing efficiency remains poorly understood. This study aims to explore the impact o...