Vol. 20, Issue 2
2026
ID: fDDKh
Helena K. Fischer, Sunil Bhattacharya, Zhao Ming-Wei
The dynamic interactions between organelles are crucial for maintaining cellular homeostasis and function. This study investigates the crosstalk between mitochondria and lysosomes, two vital organelles involved in energy metabolism and cellular waste...
Vol. 20, Issue 2
2026
ID: jkbZ3
Dr. Arjun V. Desai, Li-Xiu Zhang, Prof. Miriam van der Hoek
DNA repair is critical for maintaining genomic integrity, with poly(ADP-ribose) polymerase (PARP) playing a pivotal role in the repair of DNA double-strand breaks (DSBs). This study aims to delineate the mechanisms by which PARP facilitates DSB repai...
Vol. 20, Issue 2
2026
ID: xfp8s
Sven M. Jansen, Aria K. Patel, Li Wei-Hua
Understanding the dynamics of protein folding is crucial for elucidating the mechanisms underlying many biological processes and diseases. This study focuses on the role of hydrophobic interactions in the folding pathways of globular proteins. Using ...
Vol. 19, Issue 12
2025
ID: 82fwa
Karl-Heinz M. Neumann, Ling Xiaofeng, Priya M. Das
The complex interplay between the MAPK and PI3K/Akt signaling pathways plays a critical role in cellular processes such as proliferation, differentiation, and survival. Despite extensive research, the precise mechanisms of crosstalk remain elusive. T...
Vol. 19, Issue 12
2025
ID: 9DnJz
Ingrid Hansen-Berg, Chukwuemeka Okafor, Sakura Yamamoto
Stem cells possess the unique ability to differentiate into various cell types, rendering them crucial for regenerative medicine. The Wnt signaling pathway is pivotal in regulating stem cell fate, though its precise role in lineage specification rema...
Vol. 19, Issue 10
2025
ID: F8Xvk
Hannes F. Müller, Aditi R. Nair, Zhang Min-Jie
The intricate process of RNA splicing is crucial for the generation of mature messenger RNA (mRNA), yet the influence of small nuclear RNA (snRNA) modifications on splicing efficiency remains poorly understood. This study aims to explore the impact o...